Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor
نویسندگان
چکیده
منابع مشابه
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Regulatory T (Treg) cells suppress inflammatory immune responses and autoimmunity caused by self-reactive T cells. The key Treg cell transcription factor Foxp3 is downregulated during inflammation to allow for the acquisition of effector T cell-like functions. Here, we demonstrate that stress signals elicited by proinflammatory cytokines and lipopolysaccharides lead to the degradation of Foxp3 ...
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ژورنال
عنوان ژورنال: Immunity
سال: 2009
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2009.09.022